Planning an Italy road trip but donโt know where to start? Youโre in the right place! This Italy road trip itinerary for 10 days is packed with iconic cities, hidden gems, and scenic routes thatโll make your adventure unforgettable.
Get ready to explore Romeโs ancient history, Tuscanyโs rolling hills, the charming Cinque Terre coast, and much moreโall at your own pace. Buckle up and letโs dive into your dream Italian road trip!
Day 1 & 2: Rome
Rome is the perfect starting point for your road trip adventure. With its rich history, stunning architecture, and bustling streets, Rome will leave you awe-inspired.

What to See:
- The Colosseum and Roman Forum for ancient Roman history.
- Vatican City for the Sistine Chapel and St. Peterโs Basilica.
- Trevi Fountain and Spanish Steps for a leisurely evening walk.
Travel Tip: Rome traffic can be hectic. Itโs best to park your rental car outside the city center and explore on foot or by using public transportation.
Spend two days soaking in the cityโs treasures before hitting the road for the next leg of your trip.
Related Post: Getting Around Rome Efficiently and Easily
Day 3: Rome to Tuscany via Orvieto
On Day 3, head north to Tuscany, stopping at Orvieto, a charming hilltop town in Umbria. Orvieto is known for its beautiful Duomo and stunning views.

Explore Orvieto:
- Visit the breathtaking Cathedral of Orvieto.
- Wander the medieval streets and explore the townโs underground caves.
After Orvieto, continue driving to Tuscany and stay in one of its picturesque towns like Montepulciano or Pienza.
Day 4: Tuscany Val dโOrcia
Get ready to experience the postcard-perfect landscapes of Tuscany on Day 4. The Val dโOrcia region is dotted with vineyards, rolling hills, and medieval towns.
Top Spots to Explore:
- Pienza: Famous for its Renaissance charm and pecorino cheese.
- Montepulciano: Known for its wine (try the famous Vino Nobile di Montepulciano).
- San Quirico dโOrcia: A perfect spot for those iconic Tuscan landscape photos.
Enjoy a leisurely day of driving through the countryside, stopping at wineries, and snapping stunning photos along the way.
Related Post: Small-Group Tuscany Wine Tasting Tours
Day 5: Florence
Drive to Florence, the heart of the Renaissance, on Day 5. Spend your day exploring the cityโs art, culture, and history.

Must-Visit Attractions:
- Uffizi Gallery: See masterpieces by Botticelli, Michelangelo, and da Vinci.
- Duomo di Firenze: Climb to the top for incredible views of the city.
- Piazza della Signoria: The perfect spot to relax and enjoy the lively atmosphere.
End your day with a sunset walk along the Arno River and cross the Ponte Vecchio bridge for some shopping or dining.
Day 6: Cinque Terre
On Day 6, leave the Tuscan hills behind and head to the coast for a visit to Cinque Terre, a collection of five colorful fishing villages along the Italian Riviera.

Highlights of Cinque Terre:
- Explore Riomaggiore, Manarola, Vernazza, and Monterosso.
- Hike the trails between villages for breathtaking coastal views.
- Enjoy fresh seafood by the sea.
Whether you love hiking or just relaxing by the beach, Cinque Terre offers a mix of adventure and leisure.
Related Post: How to Plan the Perfect Cinque Terre Walking Tour?
Day 7: Pisa and Lucca
Leave the coast behind and visit Pisa on your way to Lucca. This is a day filled with iconic sights and charming small towns.
- Pisa: Donโt miss the chance to see the Leaning Tower of Pisa and explore the Piazza dei Miracoli.
- Lucca: A medieval walled city perfect for a bike ride along its ancient walls.
In Lucca, youโll find a slower pace, beautiful squares, and excellent dining options.
Day 8: Bologna
Next up is Bologna, a city known for its rich culinary traditions and historic charm. Day 8 is all about indulging in Italian food and taking in Bolognaโs beauty.

What to Do:
- Stroll through Piazza Maggiore and see the impressive Basilica di San Petronio.
- Climb the Asinelli Tower for panoramic views.
- Indulge in authentic Bolognese cuisineโpasta heaven!
Bologna is the perfect place to relax, savor good food, and take in the vibrant atmosphere.
Related Post: Milan to Bologna Day Trip Experience
Day 9: Venice
On Day 9, head to Venice, the floating city known for its canals, gondolas, and unique architecture.
- Take a gondola ride through the Grand Canal.
- Visit St. Markโs Basilica and the Dogeโs Palace.
- Cross the Rialto Bridge for some shopping and scenic views.
Spend the day wandering through Veniceโs narrow streets, discovering hidden squares, and embracing the cityโs romantic vibe.
Related Post: Milan to Venice Day Trip Travel Options
Day 10: Venice Departure
Spend your final day in Venice exploring the islands of Murano (known for its glass-making) and Burano (famous for its colorful houses). Itโs a perfect way to end your 10-day road trip on a relaxed note before heading back home.
Final Tips:
- If youโre flying out of Venice, consider dropping off your rental car and taking a boat to the airport.
- Alternatively, take a scenic train ride back to Rome or Florence if thatโs your departure city.
Quick Summary of the Italy Road Trip Itinerary
- Day 1-2: Rome โ Ancient history and vibrant culture.
- Day 3: Orvieto and Tuscany โ Medieval charm and countryside.
- Day 4: Tuscany (Val dโOrcia) โ Iconic landscapes and wine.
- Day 5: Florence โ Art, history, and Renaissance beauty.
- Day 6: Cinque Terre โ Coastal beauty and hiking.
- Day 7: Pisa and Lucca โ Leaning Tower and medieval walls.
- Day 8: Bologna โ Food heaven and historic streets.
- Day 9-10: Venice โ Romantic canals and stunning architecture.
Quotation to Inspire Your Journey
“Italy is a dream that keeps returning for the rest of your life.” โ Anna Akhmatova
This 10-day Italy road trip itinerary will give you a taste of Italyโs diverse beauty, from historic cities to coastal towns, and lush countryside. Whether itโs your first visit or a return trip, Italyโs charm will surely make it unforgettable.
Ready to hit the road? Pack your bags and start your Italian adventure today!